Low-dose hormone therapy and menopausal symptoms: the ongoing quest for relief.

238 Longitudinal changes in menopausal symptoms comparing women randomized to low-dose oral conjugated estrogens or transdermal estradiol plus micronized progesterone versus placebo: the Kronos Early Estrogen Prevention Study Nanette Santoro, MD, Amanda Allshouse, MS, Genevieve Neal-Perry, MD, PhD, Lubna Pal, MD, Rogerio A. Lobo, MD, Frederick Naftolin, MD, PhD, Dennis M. Black, PhD, Eliot A. Brinton, MD, Matthew J. Budoff, MD, Marcelle I. Cedars, MD, N. Maritza Dowling, PhD, Mary Dunn, RN, Carey E. Gleason, PhD, Howard N. Hodis, MD, Barbara Isaac, RN, Maureen Magnani, RN, JoAnn E. Manson, MD, DrPH, Virginia M. Miller, PhD, MSc, Hugh S. Taylor, MD, PhD, Whitney Wharton, PhD, Erin Wolff, MD, MSc, Viola Zepeda, RN, and S. Mitchell Harman, MD, PhD Both oral conjugated estrogen and transdermal estradiol regimens were effective in reducing hot fl ashes and night sweats, intermittently effective in reducing insomnia, and ineffective in reducing irritability associated with menopause.